Data analysis will be conducted to determine the best day to fly around the holiday season. Factors that are studied include on-time arrival, airline choice, and cost. (Mac OS X 10.10.4, Python 2.7) – Oliver Schafeld Jul 3 '15 at 20:59. I had to also then run pip install -upgrade pip – thorr18 Jan 20 '16 at 4:48. Is pip depended on python version? I installed python3, but this command seems to be using python2. Pip is installed successfully, though.
This was a joint meeting Organised by SCI's Fine Chemicals Group and RSC's Chemical Information and Computer Applications Group. Held at Imperial War Museum, Duxford, UK, on Wednesday 12 October 2016. This was an excellent meeting and the conference centre at Duxford was superb, many participants arrived early to have a wander around the historic collection of aeroplanes.
Wampus mac os. Paul Mortenson (Astex) described the informatics platform that Astex have built to support their drug discovery group. Astex did a detailed analysis of their needs and decided that at the time no commercial vendor was suitable. In particular they wanted an ease of use and responsiveness that they felt required a bespoke design. They designed the system to be entirely within a web-browser since this meant there was no need to install anything specific on the desktop, tablet or smart phone. Responsiveness was a important consideration, and having all the servers locally critical. Users were very familiar and comfortable with a web environment. Since Astex is very much focused on structure-based design as well as the usual tables and spreadsheets they needed a 3D molecule viewer, for this they used OpenAstexViewer (http://openastexviewer.net/web/) M.J.Hartshorn, JCAMD, 16, 871 (2002). This provides high quality display of both small molecules and proteins, it can also provide shaded molecular surfaces, with transparency and property mapping and protein schematics, and can be controlled using javascript.
Isabelle Giraud (Actelion) then described DataWarrior (http://www.openmolecules.org) a freely available open source cross platform data analysis tool that understands chemistry, it provides an efficient way to search, sort and analyse structure-activity data. DataWarrior was developed at Actelion and it is highly integrated into their drug discovery platform, in 2014 it was decided to release DataWarrior without the integration layer as a stand-alone tool to the public. Actelion made the decision to open source DataWarrior in an effort to help development.
Matt Segall (Optibrium) gave a very interesting presentation dealing with the critical issue of decision making when the data/information is uncertain. He also made the important point that with most experimental data or calculated properties it is as important to understand the confidence in the score as the score itself. He then gave a demonstration of the desktop tool StarDrop (http://www.optibrium.com/stardrop/) that can be used for multi-parameter optimization (MPO) in which the relative importance of each parameter can be fine-tuned to give an overall score.
Julian Blagg (The institute for Cancer Research) gave a great talk describing the informatics platform at the ICR. Quantum flux mac os. After many years with data held in multiple spreadsheets, presentations, reports they decided they needed a platform that would allow them to share data seamlessly with both internal and external scientists. After careful review of the options they decided to go forward with the Dotmatics platform (http://www.dotmatics.com). He described the initial set-up that that allowed users to browse biological data and link to chemical structures. This has now been expanded to include electronic notebooks and also the capture of high content screening data. The emphasis has been very much ease of use and unobtrusive capture of information. An added benefit has been the ability to share project specific data easily with external collaborators.
Shooter Mortenson Mac Os 7
Subsequently CRUK has decided to roll this out across all the research labs. Julian highlighted that CRUK is a particularly enlightened research funding agency, recognizing that sharing and long-term storage and retrieval of data is a mission critical activity.
Vivienne Allen (Charles River Laboratories) gave an interesting talk on the tools used in screening library design, in particular in the design of soft-focus libraries. These are small libraries designed to target a specific protein class (e.g. GPCR, Kinase, Epigenetic). They use a combination of cheminformatic tools to explore literature sources (e.g. ChEMBL) and fragment known ligands to identify interesting substituents. These are combined with novel scaffolds and the subsequent virtual libraries evaluated using docking to prioritize targets.
Jerome Hert (Roche) gave a talk on the impact of computer aided drug discovery (CADD) at Roche. The process was defined as Design, Synthesis, Testing, Analysis steps and there are opportunities for CADD to contribute to all steps. The presentation used examples from different projects in illustration.
Al Dossetter (Medchemica), Medchemica have used ADME/T data from a consortium of pharma companies and applied a matched molecular pairs analysis (MMPA) to define a set of rules for favorable transformations. (http://dx.doi.org/10.1016/j.drudis.2013.03.003) They can apply these rules to novel targets to suggest new compounds that would be worth making in an unbiased manner. Their analysis showed that whilst the data from an individual company provided on a very limited set of useful rules, combining data from multiple sources resulted a greater than additive number of rules.
David Leahy (Discovery Bus Ltd.) gave a thought-provoking final talk in which he argued the large pharma companies should be investing in artificial intelligence (AI) to replace medicinal chemists in drug design. There was an unresolved discussion about the patentability of molecules suggested by AI.
Welcome Red Wolves to the Cyber Systems Operations Course! Here you will find reporting instructions as we navigate with COVID19 protocols in place.
ABOUT THIS COURSE
This course is designed to be conducted online, with either face-to-face, or online testing, labs or progress checks. The primary learning management system we use is AETC Blackboard. Some features in blackboard we will use is the Q & A portion, discussion panel, blackboard collaborate ultra, and the instructor grading center.
ACCESSING THIS COURSE
You must have a Microsoft Windows or Mac OS, running Chrome web browser, for the online portion of this course using Blackboard. Any student without a device or network access will need to physically report to Thompson Hall, room 256 to be assigned a work area with a computer and network access. The credentials to login to this system are:
Site: aetc.blackboard.com
Username: Use same account created in IT Fundamentals.
Password: Your password will be the same as you had in IT Fundamentals.
If you have any account or password issues, contact one of the Instructor Supervisors listed at the bottom of this page.
PRIOR SERVICE STUDENTS: Prior to entering the course, please email the Instructor Supervisors (listed below) with the following information (for accountability and recall purposes):
Name, Grade, Billeting Information (Bldg & Room), Contact Phone Number.
For recall and the ability to push course related information, it is requested you use Slack. Here is the link for the invitation:
https://join.slack.com/t/336tdy/shared_invite/zt-h2f2x02a-Sw_8qABNbUCcgoFRt02LFw
On Day 1 of Block 1, we will conduct orientation in the 2nd Floor Auditorium (Room 230). Orientation is at 0645L on Monday and Wednesday class start dates and 0815L on Tuesday, Thursday, and Friday class start dates. It is your responsibility to ensure you can login to Blackboard prior to Orientation
Shooter Mortenson Mac Os Catalina
.Once you have logged into Blackboard, you should see a list of courses you are enrolled in. Select your class '21###' for Cyber Systems Operations.
The ground is falling!!! mac os. Next navigate to the left-hand panel and select Virtual Classroom. (See Image Below)
Then, click on the Course Room link and select join. When prompted, you will enter your name as [Rank] [Last Name]. (See Image Below)
Shooter Mortenson Mac Os Download
You will see a virtual classroom environment like the one below with your fellow students and your moderators are your Instructors. (See Image Below)
The Collaboration Panel at the bottom has several options:
Jerome Hert (Roche) gave a talk on the impact of computer aided drug discovery (CADD) at Roche. The process was defined as Design, Synthesis, Testing, Analysis steps and there are opportunities for CADD to contribute to all steps. The presentation used examples from different projects in illustration.
Al Dossetter (Medchemica), Medchemica have used ADME/T data from a consortium of pharma companies and applied a matched molecular pairs analysis (MMPA) to define a set of rules for favorable transformations. (http://dx.doi.org/10.1016/j.drudis.2013.03.003) They can apply these rules to novel targets to suggest new compounds that would be worth making in an unbiased manner. Their analysis showed that whilst the data from an individual company provided on a very limited set of useful rules, combining data from multiple sources resulted a greater than additive number of rules.
David Leahy (Discovery Bus Ltd.) gave a thought-provoking final talk in which he argued the large pharma companies should be investing in artificial intelligence (AI) to replace medicinal chemists in drug design. There was an unresolved discussion about the patentability of molecules suggested by AI.
Welcome Red Wolves to the Cyber Systems Operations Course! Here you will find reporting instructions as we navigate with COVID19 protocols in place.
ABOUT THIS COURSE
This course is designed to be conducted online, with either face-to-face, or online testing, labs or progress checks. The primary learning management system we use is AETC Blackboard. Some features in blackboard we will use is the Q & A portion, discussion panel, blackboard collaborate ultra, and the instructor grading center.
ACCESSING THIS COURSE
You must have a Microsoft Windows or Mac OS, running Chrome web browser, for the online portion of this course using Blackboard. Any student without a device or network access will need to physically report to Thompson Hall, room 256 to be assigned a work area with a computer and network access. The credentials to login to this system are:
Site: aetc.blackboard.com
Username: Use same account created in IT Fundamentals.
Password: Your password will be the same as you had in IT Fundamentals.
If you have any account or password issues, contact one of the Instructor Supervisors listed at the bottom of this page.
PRIOR SERVICE STUDENTS: Prior to entering the course, please email the Instructor Supervisors (listed below) with the following information (for accountability and recall purposes):
Name, Grade, Billeting Information (Bldg & Room), Contact Phone Number.
For recall and the ability to push course related information, it is requested you use Slack. Here is the link for the invitation:
https://join.slack.com/t/336tdy/shared_invite/zt-h2f2x02a-Sw_8qABNbUCcgoFRt02LFw
On Day 1 of Block 1, we will conduct orientation in the 2nd Floor Auditorium (Room 230). Orientation is at 0645L on Monday and Wednesday class start dates and 0815L on Tuesday, Thursday, and Friday class start dates. It is your responsibility to ensure you can login to Blackboard prior to Orientation
Shooter Mortenson Mac Os Catalina
.Once you have logged into Blackboard, you should see a list of courses you are enrolled in. Select your class '21###' for Cyber Systems Operations.
The ground is falling!!! mac os. Next navigate to the left-hand panel and select Virtual Classroom. (See Image Below)
Then, click on the Course Room link and select join. When prompted, you will enter your name as [Rank] [Last Name]. (See Image Below)
Shooter Mortenson Mac Os Download
You will see a virtual classroom environment like the one below with your fellow students and your moderators are your Instructors. (See Image Below)
The Collaboration Panel at the bottom has several options:
- The Chat Bubble where you can chat with the classroom or have a one-on-one discussion with an instructor.
- The People Icon where you can see who is in the classroom
- The Share Icon which allows you to share your screen when you are testing online or want to show an instructor something you are having trouble with.
- The Settings Icon for adjusting your microphone and video within the Collaboration tool.
Shooter Mortenson Mac Os X
In the middle of the black screen, you have more options:
- First is your Image Icon. This can be clicked on to indicate mood, telling the instructor to slow down, or answering yes/no to a question.
- The Microphone Icon turns audio for yourself on and off. Please remember to always mute yourself when not using.
- The Video Icon icons will turn on video for yourself.
- The Raise Hand Icon for raising hand during lecture to ask a question. This will alert the room with a special noise and is useful for many things. Your instructors may use this to indicate you are in the room during roll call.
Instructor Supervisor CONTACTS:
If you have any questions concerning this class:
Mr. Jeff Mortenson, email: jeffrey.mortenson.1@us.af.mil, 228.377.1353
TSgt Jonathan King, email: jonathan.king.17@us.af.mil, 228.377.0931
TSgt Caleb Todd, email: caleb.todd@us.af.mil. 228.377.5672
